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General Chemistry ›› 2016, Vol. 2 ›› Issue (1): 31-37.DOI: 10.21127/yaoyigc20150014

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Multifunctional Lymph-Targeted ZnO:Gd@Hyaluronic Acid Nanospheres: Preparation and Application in Tumor Diagnose

Jiejun Cheng,†,a Huajuan Zhang,†,b Jiong Zhu,a Lijun Qian,a Qing Lu,a Guangyu Wu,a Jianrong Xu,*,a Jun Zhu*,b()   

  1. a Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
    b National Engineering Research Center for Nanotechnology, Shanghai 200241, China
  • Received:2015-12-10 Accepted:2016-01-18 Online:2016-03-31 Published:2016-03-31
  • Contact: Jun Zhu


A novel multi-modal lymph-targeted contrast agent, ZnO:Gd@hyaluronic acid (HA) nanospheres, is prepared by Gd dopped ZnO quantum dot, modified by silica shell and grafted by HA molecule. The physicochemical properties are characterized and the lymphatic targeting is evaluated in vitro. Moreover, the contrast agent is used for in vivo lymphoma magnetic resonance imaging (MRI). The results show that the ZnO:Gd@HA nanospheres with 19% of quantum yield and 5.8 mM–1•s–1 of relaxivity could be used for in vivo lymphatic targeting studies. Furthermore, they are highly targeted to lymph system in vitro and in vivo, and highlight their MRI in lymph tumor. Thus, the novel MRI contrast agent can be taken up selectively by lymphatic system and used as a potential multi-modal contrast agent in lymphatic system.

Key words: multi-modal imaging, lymph-targeted, hyaluronic acid, quantum dot

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