Home  Guidelines for Reviewers About the Journal News Editorial Board Aims & Scope Subscription Contact us Announcement Peer Review Policy Content
Early Edition  //  Current Issue  //  Archives  //  Most Read
Cover Illustration
2016, Vol.2  No.1
The cover picture shows that perfluorotripropylamine (FC-3283), a kind of perfluorocarbon as an oxygen carrier, is encapsulated in a copolymer using PEG to modify PLGA to prepare a PLGA-PEG/FC-3283 emulsion for highly efficient reoxygenation to cell. Because of the oxygen carry and release ability of PLGA-PEG/FC-3283 emulsion, the cell viability was significantly increased through PLGA-PEG/FC-3283 emulsion administration after the cells treated with hypoxia.
Online ISSN: 2414-3421
  About the Journal
    » About Journal
    » Editorial Board
    » Online Submission
    » Guidelines for Authors
    » Download Templates
    » Copyright Agreement
    » Guidelines for Reviewers
    » Online Peer Review
    » Online Editor Work
  Editorial Office
  Virtual Special Issues
  • Table of Content
      31 March 2016, Volume 2 Issue 1 Previous Issue    Next Issue
    For Selected: View Abstracts Toggle Thumbnails
    Contents: Gen. Chem. 1/2016
    General Chemistry. 2016, 2 (1): 29-30.   DOI: 10.21127/yaoyigc20169001
    Abstract   PDF (215KB) ( )
    Related Articles | Metrics
    Full Papers
    Multifunctional Lymph-Targeted ZnO:Gd@Hyaluronic Acid Nanospheres: Preparation and Application in Tumor Diagnose
    Jiejun Cheng, Huajuan Zhang, Jiong Zhu, Lijun Qian, Qing Lu, Guangyu Wu, Jianrong Xu, Jun Zhu
    General Chemistry. 2016, 2 (1): 31-37.   DOI: 10.21127/yaoyigc20150014
    Abstract   HTML   PDF (512KB) ( )

    A novel multi-modal lymph-targeted contrast agent, ZnO:Gd@hyaluronic acid (HA) nanospheres, is prepared by Gd dopped ZnO quantum dot, modified by silica shell and grafted by HA molecule. The physicochemical properties are characterized and the lymphatic targeting is evaluated in vitro. Moreover, the contrast agent is used for in vivo lymphoma magnetic resonance imaging (MRI). The results show that the ZnO:Gd@HA nanospheres with 19% of quantum yield and 5.8 mM–1•s–1 of relaxivity could be used for in vivo lymphatic targeting studies. Furthermore, they are highly targeted to lymph system in vitro and in vivo, and highlight their MRI in lymph tumor. Thus, the novel MRI contrast agent can be taken up selectively by lymphatic system and used as a potential multi-modal contrast agent in lymphatic system.

    References | Related Articles | Metrics
    Preparation of Perfluorocarbon Emul-sion and Its Application in Cells Re-oxygenation
    Zhengfeng Wen, Rui Liu, Fan Yi, Yanjie Yao, Jun Guan, Dannong He, Jun Zhu, Zhaofen Lin
    General Chemistry. 2016, 2 (1): 38-43.   DOI: 10.21127/yaoyigc.20150019
    Abstract   HTML   PDF (829KB) ( )

    Perfluorotripropylamine (FC-3283), a kind of perfluorocarbon as oxygen carrier, is encapsulated in a copolymer using polyethylene glycol (PEG) to modify poly lactic-co-glycolic acid (PLGA) to prepare a PLGA-PEG/FC-3283 emulsion for highly efficient reoxygenation to cell. 1H nuclear magnetic resonance (1H NMR) spectra, Fourier transform infrared spectrum (FT-IR), transmission electron microscopy (TEM), dynamic light scattering (DLS) and high performance ion chromatography proved the formation of the PLGA-PEG and PLGA-PEG/FC-3283 emulsion. High performance ion chromatography revealed that FC-3283 content in the emulsion is 9.4%. Furthermore, CCK-8 assay was used to detect the cytotoxicity of the PLGA-PEG/FC-3283 emulsion to HCT 116 cells. Finally, the ability of oxygen supply and release of PLGA-PEG/FC-3283 emulsion was evaluated by CCK-8 asssy and fluorophotometry based on establishing hypoxia/reoxygenation model of HCT 116 cells with liquid paraffin. By detecting the cells increment rate and the content changes of reactive oxygen species (ROS) before and after reoxygenation, we explored the oxygen carry and release ability of PLGA-PEG/FC-3283 emulsion. The results showed that the cell viability increased significantly through PLGA-PEG/FC-3283 emulsion administration after the cells were treated with hypoxia.

    References | Related Articles | Metrics
    Peroxidase-Like Properties of Multiple Nano-Metallic Oxides under Various Conditions
    Ting Liu, Kunfeng Zhao, Linyu Jin, Jun Zhu, Yamei Dong, Yinan Yan, Ping Wang, Dannong He
    General Chemistry. 2016, 2 (1): 44-48.   DOI: 10.21127/yaoyigc20150020
    Abstract   HTML   PDF (390KB) ( )

    Six types of different nano-metallic oxides were studied as peroxidase-like enzyme. By changing the amounts of nano-metallic oxides, pH value, the concentration of H2O2, reaction time, and so on, the peroxidase-like characteristics of all the six nano-metallic oxides were probed, and four of them (Co3O4, CrOx, NiO, MnOx) have the oxidase-like properties in the absence of H2O2, which is of great importance in the application of degrading phenolic pollutants in waste water.

    References | Related Articles | Metrics
    Iodobenzene Dicarboxylates as Transferrable Oxygen Sources: Synthesis of α-Oxygenated Ketones from Terminal Aryl Alkynes
    Bao-Yi Ren, Daokun Zhong, Nan Guo, Weikun Duan, Shuai Song, Xue Yang
    General Chemistry. 2016, 2 (1): 49-54.   DOI: 10.21127/yaoyigc20150018
    Abstract   HTML   PDF (435KB) ( )

    A facile and efficient method for preparation of α-oxygenated ketones has been developed via the reaction of terminal aryl alkynes with various iodobenzene dicarboxylates. When bis(trifluoroacetoxy)iodobenzene (PIFA) was used, α-hydroxy ketones were obtained in high to excellent yields. The hypervalent iodine(III) reagents can function as an electrophile, transferrable O-nucleophile, and an excellent leaving group. The protocol represents a direct, atom-efficient and metal-free conversion of alkynes into α-oxygenated ketones under mild conditions.

    References | Related Articles | Metrics
    Degree of Conversion, Bond Strength and Biocompatibility of the APTES@SiO2 Strengthened Experimental Dental Adhesive
    Bin Zhang, Juan Zhou, Peicheng Xu, Ziyuan Zhu, Jun Zhu, Wenhao Qian, Dannong He
    General Chemistry. 2016, 2 (1): 55-63.   DOI: 10.21127/yaoyigc20150006
    Abstract   HTML   PDF (1238KB) ( )

    The aim of this study was to investigate the effect of incorporation of the nano silica modified with (3-aminopropyl)triethoxysilane (APTES@SiO2) on the degree of conversion, bond strength and biocompatibility of an experimental dental adhesive. An amphiphilic bonding system was used as the experimental dentin bonding system. The APTES@SiO2 with diameter of 70 nm was prepared and added into the experimental dentin bonding system as nanofiller, and the effect of the modification on the stability of the nano APTES@SiO2 dispersed in the experimental adhesive was studied. In addition, the morphology, degree of conversion, bond strength to dental restorative resin and biocompatibility of the experimental adhesives containing nanofiller were tested. After modification, the dispersion stability of the nano particles in the adhesive was improved. With increasing the content of the nano APTES@SiO2, the rate of light conversion increased significantly. However, the ultimate degree of conversion, bond strength to resin and bulk compressive strength was not significantly affected. Compared with the adhesive without nanofiller, the adhesive with 2 wt% APTES@SiO2 showed better bond strength to dentin and lower polymerization shrinkage. In addition, the experimental adhesive showed slight cytotoxicity with the incorporation of APTES@SiO2, but it was attenuated at low concentration.

    References | Related Articles | Metrics
  News More  
» The special issue on Green Chemistry
» The special issue on Desalination
» The special issue on Organic Synthetic Methodology

  Journal Indexing   
Copyright © General Chemistry, All Rights Reserved.
Address: 425 East 76th Street, Apt 9E, New York, NY, 10021, United States