A novel multi-modal lymph-targeted contrast agent, ZnO:Gd@hyaluronic acid (HA) nanospheres, is prepared by Gd dopped ZnO quantum dot, modified by silica shell and grafted by HA molecule. The physicochemical properties are characterized and the lymphatic targeting is evaluated in vitro. Moreover, the contrast agent is used for in vivo lymphoma magnetic resonance imaging (MRI). The results show that the ZnO:Gd@HA nanospheres with 19% of quantum yield and 5.8 mM^–1•s^–1 of relaxivity could be used for in vivo lymphatic targeting studies. Furthermore, they are highly targeted to lymph system in vitro and in vivo, and highlight their MRI in lymph tumor. Thus, the novel MRI contrast agent can be taken up selectively by lymphatic system and used as a potential multi-modal contrast agent in lymphatic system.

Perfluorotripropylamine (FC-3283), a kind of perfluorocarbon as oxygen carrier, is encapsulated in a copolymer using polyethylene glycol (PEG) to modify poly lactic-co-glycolic acid (PLGA) to prepare a PLGA-PEG/FC-3283 emulsion for highly efficient reoxygenation to cell. ¹H nuclear magnetic resonance (¹H NMR) spectra, Fourier transform infrared spectrum (FT-IR), transmission electron microscopy (TEM), dynamic light scattering (DLS) and high performance ion chromatography proved the formation of the PLGA-PEG and PLGA-PEG/FC-3283 emulsion. High performance ion chromatography revealed that FC-3283 content in the emulsion is 9.4%. Furthermore, CCK-8 assay was used to detect the cytotoxicity of the PLGA-PEG/FC-3283 emulsion to HCT 116 cells. Finally, the ability of oxygen supply and release of PLGA-PEG/FC-3283 emulsion was evaluated by CCK-8 asssy and fluorophotometry based on establishing hypoxia/reoxygenation model of HCT 116 cells with liquid paraffin. By detecting the cells increment rate and the content changes of reactive oxygen species (ROS) before and after reoxygenation, we explored the oxygen carry and release ability of PLGA-PEG/FC-3283 emulsion. The results showed that the cell viability increased significantly through PLGA-PEG/FC-3283 emulsion administration after the cells were treated with hypoxia.

Six types of different nano-metallic oxides were studied as peroxidase-like enzyme. By changing the amounts of nano-metallic oxides, pH value, the concentration of H₂O₂, reaction time, and so on, the peroxidase-like characteristics of all the six nano-metallic oxides were probed, and four of them (Co₃O₄, CrO_x, NiO, MnO_x) have the oxidase-like properties in the absence of H₂O₂, which is of great importance in the application of degrading phenolic pollutants in waste water.

A facile and efficient method for preparation of α-oxygenated ketones has been developed via the reaction of terminal aryl alkynes with various iodobenzene dicarboxylates. When bis(trifluoroacetoxy)iodobenzene (PIFA) was used, α-hydroxy ketones were obtained in high to excellent yields. The hypervalent iodine(III) reagents can function as an electrophile, transferrable O-nucleophile, and an excellent leaving group. The protocol represents a direct, atom-efficient and metal-free conversion of alkynes into α-oxygenated ketones under mild conditions.

The aim of this study was to investigate the effect of incorporation of the nano silica modified with (3-aminopropyl)triethoxysilane (APTES@SiO₂) on the degree of conversion, bond strength and biocompatibility of an experimental dental adhesive. An amphiphilic bonding system was used as the experimental dentin bonding system. The APTES@SiO₂ with diameter of 70 nm was prepared and added into the experimental dentin bonding system as nanofiller, and the effect of the modification on the stability of the nano APTES@SiO₂ dispersed in the experimental adhesive was studied. In addition, the morphology, degree of conversion, bond strength to dental restorative resin and biocompatibility of the experimental adhesives containing nanofiller were tested. After modification, the dispersion stability of the nano particles in the adhesive was improved. With increasing the content of the nano APTES@SiO₂, the rate of light conversion increased significantly. However, the ultimate degree of conversion, bond strength to resin and bulk compressive strength was not significantly affected. Compared with the adhesive without nanofiller, the adhesive with 2 wt% APTES@SiO₂ showed better bond strength to dentin and lower polymerization shrinkage. In addition, the experimental adhesive showed slight cytotoxicity with the incorporation of APTES@SiO₂, but it was attenuated at low concentration.