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General Chemistry ›› 2019, Vol. 5 ›› Issue (4): 190015-190015.DOI: 10.21127/yaoyigc20190015

Special Issue: Bioimaging

• Minireviews • Previous Articles     Next Articles

Recent Advances on Fluorescence Imaging of Lymphatic Vasculature System

Yi Lia, Liqin Xiongb, *   

  1. a School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China;
    b Shanghai Med-X Engineering Center for Medical Equipment and Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China
  • Received:2019-07-21 Revised:2019-08-06 Online:2019-12-29 Published:2019-12-12
  • Contact: Liqin Xiong, Email: xiongliqin@sjtu.edu.cn (L. X.)

Abstract: Lymphatic vasculature system has attracted extensive attention due to its important role in some pathological changes such as lymphedema, immune dysfunction, gut malabsorption and lymph node metastasis, etc. With the continuous development of fluorescence imaging technology, it has been widely used in the study of lymphatic vessels structure, morphology, and function both in preclinical and clinical. Fluorescence imaging can help researchers and clinicians to know the morphological and functional status of lymphatic vessels, explore the role of lymphatic vessels in various lymph-related diseases, and help diagnosis the state of lymphatic vessels in patients and formulate further treatment plan. Herein, we describe the usage and recent advances of fluorescence imaging technology including immune fluorescence imaging, optical coherence tomography, near-infrared fluorescence imaging in ex vivo and in vivo lymphangiography, and discuss the future applications of fluorescence imaging in lymphatic vasculature imaging.

Key words: lymphatic vasculature system, fluorescence imaging, lymphangiography

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