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General Chemistry ›› 2016, Vol. 2 ›› Issue (4): 99-106.DOI: 10.21127/yaoyigc20160080

Special Issue: Bioimaging

• Minireviews • Previous Articles     Next Articles

Recent Advances on Near-Infrared-Emitting Poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] Polymer Dots for in vivo Imaging

Liqin Xiong*,a,b()   

  1. a Nano Biomedical Research Center, School of Biomedical Engineering, Med-X Research Institute,Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China
    b Department of Nuclear Medicine, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University,Shanghai 200025, China
  • Received:2016-10-28 Accepted:2016-11-07 Online:2016-11-24 Published:2016-11-24
  • Contact: Xiong Liqin

Abstract:

Conjugated polymer dots emerge as attractive molecular imaging nanoprobes in living animals for their excellent optical properties including bright fluorescence intensity, excellent photostability, high emission rates, and low intrinsic cytotoxicity. This mini-review summarizes recent advances on near-infrared-emitting poly[2-methoxy-5- (2-ethylhexyloxy)-1,4-phenylenevinylene] polymer dots for in vivo bioimaging. The preparation of near-infrared MEH-PPV polymer dots is firstly discussed, followed by some examples of their applications ranging from lymph node mapping and tumor imaging to long-term tumor tracking.

Key words: near-infrared fluorescence imaging, bioluminescence, polymer dots, lymph node mapping, tumor tracking

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