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General Chemistry

Special Issue: Metalloenzymes

• Perspective • Previous Articles     Next Articles

Protein-Pd Complexes Conjugates as Artificial Enzymes

Jose M Palomo*,a and Esteban P. Urriolabeitia*,b   

  1. a Department of Biocatalysis, Institute of Catalysis (CSIC)Marie Curie 2. Cantoblanco. Campus UAM, 28049Madrid, Spain
    b Instituto de Síntesis Quimica y Catálisis Homogénea (ISQCH, CSIC-Universidad de Zaragoza), C/Pedro Cerbuna 12, Zaragoza, E-50009, Spain
  • Received:2019-11-05 Revised:2019-11-28 Online:2020-09-15
  • Contact: Email: josempalomo@icp.csic.es (J. M. P.), esteban@unizar.es (E. P. U.)
  • Supported by:

Abstract: The combination of enzymes and palladium organometallic complexes has been recently developed for the creation of new types of artificial metalloenzymes. Different methods considering the kind of protein used, from a core protein to an enzyme, or the strategies for the selective insertion of the organometallic complex from direct Pd bonding to protein amino acid, affinity interactions or covalent attachment by a Pd complex ligand have been developed. This methodology affords new Pd catalysts with highest selectivity and activity in different reactions at milder conditions compared with the free Pd complexes.


Key words: metalloenzymes, palladium complexes, hybrids, organometallics

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