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Ultrasensitive in-vitro Detection Assay for Non-invasive Alzheimer’s Disease Diagnosis
See-Lok Ho,a Hei-Nga Chan,a Hung-Wing Li,*,b and Man-Shing Wong*,b
a MIND and Tech, Ltd., Fo Tan, Hong Kong, China
b Hong Kong Baptist University, Department of Chemistry, Kowloon Tong, Hong Kong, China
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Abstract  Alzheimer’s disease (AD) is the most prevalent cause of dementia. According to the Alzheimer’s Disease Association, there are over 37 million patients currently suffering from AD. To date, there is still no standard method for accurate AD diagnosis. Detection of biomarkers has become a new trend for disease diagnosis as research has shown that alternation of the expression profile of biomarkers occurs over 10 years before the development of any symptoms. Recently, there is a considerable development in the field of ultrasensitive detection assay for AD diagnosis. This perspective gives an updated review of the current state of development on body fluid-based detection assay for non-invasive AD diagnosis.
Keywords Alzheimer’s disease      biomarkers      non-invasive      diagnosis      immunoassay     
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Corresponding Authors: hwli@hkbu.edu.hk (H. W. L.), mswong@hkbu.edu.hk (M. S. W.)   
Online First Date: 15 December 2019   
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See-Lok Ho
Hei-Nga Chan
Hung-Wing Li
Man-Shing Wong
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See-Lok Ho,Hei-Nga Chan,Hung-Wing Li, et al. Ultrasensitive in-vitro Detection Assay for Non-invasive Alzheimer’s Disease Diagnosis[J]. General Chemistry, 15 December 2019. [Epub ahead of print] doi: 10.21127/yaoyigc20190035.
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http://www.genchemistry.org/EN/10.21127/yaoyigc20190035    
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