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General Chemistry ›› 2018, Vol. 4 ›› Issue (1): 180002-180002.DOI: 10.21127/yaoyigc20180002

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Preparation of An Ibuprofen Polysaccharide Hydrogel Based on a Dual-Role Cross-Linker

Yiou Tao, Yang Han, Ting Wang()   

  1. Department of Chemistry, Northeast Forestry University, Harbin, Heilongjiang 150040, China
  • Received:2018-01-10 Accepted:2018-03-08 Online:2018-03-21 Published:2018-03-22


A polysaccharide hydrogel is prepared by mixing hydroxyethylcellulose (HEC), ibuprofen (IBU) and ethylenediamine-β-cyclodextrin (EDA-CD) in water with special sequence at certain concentration. The biocompatible polymer of HEC is used as the hydrogel matrix. IBU is a poorly water-soluble drug, which is widely applied to the clinical. EDA-CD with dual-role is used as cross-linker and hydrophobic drug carrier. FTIR, 1H NMR and 13C NMR were used to characterize EDA-CD. Hildebrand-Benesi equation and phase solubility method were used to investigate the binding mode of EDA-CD and IBU. The binding constant of EDA-CD and IBU is 4055 L·mol-1, the stoichiometry ratio is 1:1, and the water solubility of IBU in EDA-CD solution can reach 5 g in 100 mL of water. SEM was used to observe the surface morphology of the dry hydrogel. A porous surface analysis of the dry hydrogel has revealed that the molecule weight and the amount of the HEC polymer affect obviously the gelation process. UV spectrophotometer was used to detect the content of IBU in the hydrogel. The in vitro release test of IBU in hydrogel was investigated and some suitable kinetic models are used for explaining the releasing mechanism.


Key words: hydrogels, cross-linker, hydroxyethylcellulose, cyclodextrins, ibuprofen

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