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Simple and Efficient Eco-Friendly Multigram Procedure for Preparation of Piperazine Hydrochloride, an Important Building Block in Medicinal Chemistry
Cristiane F. da Costa, Marcus Vinicius N. de Souza, Victor Facchinetti, and Claudia Regina B. Gomes
General Chemistry    2021, 7 (3): 210004-210004.   DOI: 10.21127/yaoyigc20210004
Abstract193)      PDF (675KB)(346)       Save
This work describes the synthesis of piperazine hydrochloride in multigram scale and high yields with promising industrial applications. This methodology is simple, fast, safe, low cost, and applicable to the synthesis of a wide variety of piperazine derivatives, being very useful in medicinal chemistry and other fields.
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