Abstract: Enzymes are biomolecules with remarkable catalytic properties, which play a critical role in the driving toward green and sustainable methodologies for chemicals manufacturing. In spite of many advantages in enzyme catalysis, it remains fragile entities. These defects limit the widespread application of enzymes in industry. It is a favorable choice to immobilize the enzyme on solid supports to enhance its activity and stability. Metal-organic frameworks (MOFs) are excellent porous materials that possess tunable porosity, desirable functionality, extremely high surface area, and excellent chemical/thermal stability. It has made great achievements in the encapsulation of enzymes in the past few years. In this article, we focus on the recent advances of these composites, especially in the encapsulated strategies and mechanism, and future perspectives are discussed as well

Key words: metal-organic frameworks, enzyme, nanomaterials, immobilization