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General Chemistry ›› 2017, Vol. 3 ›› Issue (1): 118-122.DOI: 10.21127/yaoyigc20160003

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Progress of Lymph-Targeted Contrast Agents and Their Application in Diagnosis of Tumor Lymphatic Metastasis

Ying Zhang,a,b Jie Wang,a Jiejun Cheng,c  Yu Qiao,a,b Gang Huang,d,* Jun Zhu,b,* Dannong Hea,b,*()   

  1. a College of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
    b National Engineering Research Center for Nanotechnology, Shanghai 200241, China
    c Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai 200127, China
    d Shanghai University of Medicine & Health Sciences, Shanghai 200241, China
  • Received:2016-10-02 Accepted:2016-11-30 Online:2017-03-05 Published:2017-03-06
  • Contact: Gang Huang,Jun Zhu,Dannong He
  • Supported by:
    These authors contributed equally to this work.


Lymph node metastasis is an important aspect for tumor metastasis, which accounts for a majority of cancer death. Non-invasive imaging techniques play a more important role than traditional lymph node biopsy for diagnosis of metastatic lymph nodes. However, non-specific information of lymph node such as size and morphology could only be obtained in traditional imaging techniques, which always bring about mission detection. Thus, lymph-targeted contrast agents are attracting much interest. Presently, most contrast agents are based on the mechanism of passive targeting, which could be affected by the number and function of macrophages in the lymph nodes. Therefore, it is beneficial to study the tumor lymphatic metastases through developing new lymph-targeted contrast agents, which could bring fresh prospect for tumor diagnosis and treatment. The paper reviews the progress of lymph-targeted contrast agents and their diagnosis technology for cancer.

Key words: lymph-targeted contrast agents, tumor lymphatic metastasis, diagnosis techniques

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