Simple and Efficient Eco-Friendly Multigram Procedure for Preparation of Piperazine Hydrochloride, an Important Building Block in Medicinal Chemistry

doi:10.21127/yaoyigc20210004

General Chemistry ›› 2021, Vol. 7 ›› Issue (3): 210004-210004.DOI: 10.21127/yaoyigc20210004

Special Issue: Green Chemistry

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Simple and Efficient Eco-Friendly Multigram Procedure for Preparation of Piperazine Hydrochloride, an Important Building Block in Medicinal Chemistry

Cristiane F. da Costa, Marcus Vinicius N. de Souza,^*Victor Facchinetti, and Claudia Regina B. Gomes

Farmanguinhos/Fiocruz, R. Sizenando Nabuco, 100, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil

Received:2020-04-27 Accepted:2021-05-19 Online:2021-08-30 Published:2021-06-11
Contact: *, Email: mvndesouza@gmail.com (M. V. N. S.)

Abstract

Abstract: This work describes the synthesis of piperazine hydrochloride in multigram scale and high yields with promising industrial applications. This methodology is simple, fast, safe, low cost, and applicable to the synthesis of a wide variety of piperazine derivatives, being very useful in medicinal chemistry and other fields.

Key words: piperazine, medicinal chemistry, chloridrate, alkylation and acylation, green chemistry

Cristiane F. da Costa, Marcus Vinicius N. de Souza, Victor Facchinetti, and Claudia Regina B. Gomes. Simple and Efficient Eco-Friendly Multigram Procedure for Preparation of Piperazine Hydrochloride, an Important Building Block in Medicinal Chemistry[J]. General Chemistry, 2021, 7(3): 210004-210004.

References

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Simple and Efficient Eco-Friendly Multigram Procedure for Preparation of Piperazine Hydrochloride, an Important Building Block in Medicinal Chemistry

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