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General Chemistry ›› 2021, Vol. 7 ›› Issue (3): 210004-210004.DOI: 10.21127/yaoyigc20210004

Special Issue: Green Chemistry

• Reports • Previous Articles     Next Articles

Simple and Efficient Eco-Friendly Multigram Procedure for Preparation of Piperazine Hydrochloride, an Important Building Block in Medicinal Chemistry

Cristiane F. da Costa, Marcus Vinicius N. de Souza,* Victor Facchinetti, and Claudia Regina B. Gomes   

  1. Farmanguinhos/Fiocruz, R. Sizenando Nabuco, 100, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil
  • Received:2020-04-27 Accepted:2021-05-19 Online:2021-08-30 Published:2021-06-11
  • Contact: *, Email: mvndesouza@gmail.com (M. V. N. S.)

Abstract: This work describes the synthesis of piperazine hydrochloride in multigram scale and high yields with promising industrial applications. This methodology is simple, fast, safe, low cost, and applicable to the synthesis of a wide variety of piperazine derivatives, being very useful in medicinal chemistry and other fields.

Key words: piperazine, medicinal chemistry, chloridrate, alkylation and acylation, green chemistry

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