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C—H Activation, a New Strategy for Synthesis of 3-Substituted Phthalides

Qianqian Sun, Runqing Zhu, Shuyu Hu, and Lizhen Fang*   

  1. School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, China
  • Received:2020-06-24 Revised:2020-07-25 Online:2021-03-29 Published:2021-03-29
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Abstract: Phthalides are an important class of compounds owing to their role as the key structural motifs in bioactive natural products and pharmaceutical synthesis. C—H activation has become a promising strategy for preparation of phthalides due to its advantages of high efficiency and atomic economy compared with the traditional methods. In this paper, we summarized recent advances on synthesis of 3-substituted phthalides via C—H activation according to different transition metal catalytic systems.


Key words: synthesis, 3-substituted phthalides, C—H activation, catalysis

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