Home  Guidelines for Reviewers About the Journal News Editorial Board Aims & Scope Subscription Contact us Announcement Peer Review Policy Content
 
Early Edition  //  Current Issue  //  Archives  //  Most Read

General Chemistry ›› 2016, Vol. 2 ›› Issue (1): 49-54.DOI: 10.21127/yaoyigc20150018

• Full Papers • Previous Articles     Next Articles

Iodobenzene Dicarboxylates as Transferrable Oxygen Sources: Synthesis of α-Oxygenated Ketones from Terminal Aryl Alkynes

Bao-Yi Ren,*,a,b Daokun Zhong,a Nan Guo,a Weikun Duan,a Shuai Song,a Xue Yangb   

  1. a Key Laboratory of Inorganic Molecule-Based Chemistry of Liaoning Province, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, China
    b Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024, China
  • Received:2015-12-22 Accepted:2016-01-15 Online:2016-03-31 Published:2016-03-31
  • Contact: Bao-Yi Ren

Abstract:

A facile and efficient method for preparation of α-oxygenated ketones has been developed via the reaction of terminal aryl alkynes with various iodobenzene dicarboxylates. When bis(trifluoroacetoxy)iodobenzene (PIFA) was used, α-hydroxy ketones were obtained in high to excellent yields. The hypervalent iodine(III) reagents can function as an electrophile, transferrable O-nucleophile, and an excellent leaving group. The protocol represents a direct, atom-efficient and metal-free conversion of alkynes into α-oxygenated ketones under mild conditions.

Key words: iodobenzene dicarboxylates, transferrable oxygen sources, #cod#x003B1;-oxygenated ketones

沪ICP备15041762号-2
Copyright © General Chemistry, All Rights Reserved.
Address: 425 East 76th Street, Apt 9E, New York, NY, 10021, United States